The screenshot above provides the location of Vault 63 on the Fallout 76 map. The enemies in this part of the Appalachia are sometimes tough to battle so you may want to take a higher ranked friend with you unless you don’t mind dying a few times.
Be sure to check out some of the links below to see where the other Vaults are located throughout the Appalachia.

Where to find the ingredients to make Berry Mentats - Map
Where to find/farm Beaver Locations in Fallout 76?
Fallout Pip-Boy 2000 Mk VI Construction Kit
In Fallout 76 when do the Daily Quests Reset/Restart?
List of Nuka World on Tour Plans, Recipes & Weapons - Fallout 76
How to Craft Legendary Weapons in Fallout 76
Where to find/farm Nuclear Material Locations in Fallout 76
Where is Minerva Located on the map in Fallout 76